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Īs a child, MacFarlane developed an interest in illustration, and at the age of two he began drawing cartoon characters such as Fred Flintstone and Woody Woodpecker. She later worked in the college guidance and admissions offices at the Kent School, a selective college preparatory school, where Ronald was a teacher. They moved to Kent in 1972, where Ann began working in the admissions office at South Kent School. MacFarlane's parents met in 1970 when they lived and worked in Boston, Massachusetts, and married later that year. His maternal grandfather, Arthur Sager, competed in the 1928 Summer Olympics. He has roots in New England going back to the 1600s, and is a descendant of Mayflower passenger William Brewster. His younger sister Rachael is also a voice actress. His parents, Ronald Milton MacFarlane and Ann Perry (née Sager), were born in Newburyport, Massachusetts. MacFarlane was born and raised in Kent, Connecticut.

He received a star on the Hollywood Walk of Fame in 2019 and was inducted into the Television Hall of Fame in 2020.

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MacFarlane was executive producer of the Neil deGrasse Tyson-hosted Cosmos: A Spacetime Odyssey, an update of the 1980s Cosmos series hosted by Carl Sagan. He hosted the 85th Academy Awards in 2013 and was nominated for Best Original Song for ' Everybody Needs a Best Friend' from Ted. MacFarlane has also sung with Gwen Stefani, Meghan Trainor, Ariana Grande, and Barbra Streisand. He has frequently collaborated with artists such as Sara Bareilles, Norah Jones, and Elizabeth Gillies on his albums. MacFarlane has received five Grammy Award nominations for his work. He has released seven studio albums, in the vein of Frank Sinatra, with influences from jazz orchestrations, and Hollywood musicals beginning with Music Is Better Than Words in 2011. MacFarlane has performed as a singer at Carnegie Hall in New York City and the Royal Albert Hall in London. In 2009, he won the Webby Award for Film & Video Person of the Year. He won several awards for his work on Family Guy, including five Primetime Emmy Awards. In 2008, he created the YouTube series Seth MacFarlane's Cavalcade of Cartoon Comedy. MacFarlane made guest appearances as an actor on television series such as Gilmore Girls, The War at Home, Star Trek: Enterprise, and FlashForward. Recruited to Hollywood, he was an animator and writer for Hanna-Barbera for television series including Johnny Bravo, Cow and Chicken, Dexter's Laboratory, and the animated short Larry & Steve for What A Cartoon!.

MacFarlane is a graduate of the Rhode Island School of Design, where he studied animation. He also wrote, directed, and starred in the films Ted (2012), its sequel Ted 2 (2015), and A Million Ways to Die in the West (2014). MacFarlane is the creator and star of the television series Family Guy (since 1999) and The Orville (since 2017), and co-creator of the television series American Dad! (since 2005) and The Cleveland Show (2009–2013). Seth Woodbury MacFarlane ( / m ə k ˈ f ɑːr l ɪ n/ born October 26, 1973) is an American actor, animator, filmmaker, comedian, and singer.

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